編號(hào)：BJBAG2001
中文品名：鏈脲佐菌素 、鏈脲霉素 
英文名稱：Streptozocin 
≥75% α-anomer basis, ≥98% (HPLC), powder 
CAS號(hào) 18883-66-4 
經(jīng)驗(yàn)分子式（希爾表示法） C8H15N3O7 
分子量 265.22 

 

• 技術(shù)說(shuō)明書
   

 

基本信息

性質(zhì)

Related Categories	Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antibiotics by Mechanism of Action, Antineoplastic and Immunosuppressive Antibiotics, Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cell Signaling Enzymes, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, Interferes with DNA Synthesis, NO Donors, Nitric Oxide Donors, Nitric Oxide Metabolism, Pfizer Compounds, S, 一氧化氮代謝, 一氧化氮和細(xì)胞應(yīng)激, 抗生素, 生化試劑, 生物活性小分子, 細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)和神經(jīng)科學(xué), 細(xì)胞生物學(xué), 酶、抑制劑和底物 更多...
InChI Key	ZSJLQEPLLKMAKR-GKHCUFPYSA-N
assay	≥75% α-anomer basis
	≥98% (HPLC)
form	powder
color	white to light yellow
mp	121 °C (dec.) (lit.)
Mode of action	DNA synthesis | interferes
antibiotic activity spectrum	neoplastics
originator	Pfizer
storage temp.	−20°C

 

產(chǎn)品描述

鏈脲佐菌素或鏈脲佐菌素是從不產(chǎn)色鏈霉菌中獲得的。鏈脲佐菌素是一種葡糖胺-亞硝基脲，是一種僅通過(guò)GLUT2葡萄糖轉(zhuǎn)運(yùn)蛋白進(jìn)入細(xì)胞的DNA烷化劑。鏈脲菌素，一種致糖尿病劑，對(duì)于產(chǎn)生胰島素的胰島β-細(xì)胞具有特別的毒性。它對(duì)GLUT2陽(yáng)性神經(jīng)內(nèi)分泌腫瘤細(xì)胞具有毒性。

鏈脲菌素或鏈脲佐菌素用于誘導(dǎo)糖尿病動(dòng)物模型，該化合物可用于胰腺β細(xì)胞癌的治療，本公司所提供產(chǎn)品，僅供動(dòng)物使用。

可提供 100mg/500mg/1g三個(gè)包裝規(guī)格產(chǎn)品。

一種在胰島中可作為一氧化氮供體的含N-亞硝基化合物；誘導(dǎo)胰島素分泌細(xì)胞的死亡，產(chǎn)生糖尿病動(dòng)物模型?？烧T導(dǎo)染色體斷裂的有效DNA甲基化劑。 對(duì)表達(dá)GLUT2葡萄糖轉(zhuǎn)運(yùn)蛋白的神經(jīng)內(nèi)分泌腫瘤細(xì)胞系具有細(xì)胞毒性。

技術(shù)規(guī)格說(shuō)明書

FT-IR Condensed Phase

FT-IR Raman

FT-NMR

S0130 - Product Information Sheet (57 KB)

安全信息

Danger

危害聲明 

 

個(gè)人防護(hù)裝備 

Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

危害碼 (歐洲) 

T

風(fēng)險(xiǎn)聲明 (歐洲) 

45

安全聲明 (歐洲) 

53-45

RIDADR 

UN 3077 9 / PGIII

WGK德國(guó) 

3

RTECS 

LZ5775000

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?

If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

How should I store Product S0130, Streptozocin, upon receipt?

Streptozocin should be stored at -20 degrees C with desiccation. The desiccant is to prevent moisture uptake which can shorten shelf-life.

How do I store solutions of Product S0130, Streptozocin?

Aqueous solutions rapidly undergo mutarotation to an equilibrium mixture of alpha- and beta-anomers. Maximum solution stability is at pH 4, with stability decreasing rapidly at higher or lower pH. Freshly prepared solutions are clear and have a light straw color. On standing, they take on a yellow to brown color and effervesce, indicating decomposition. Solutions should be prepared just before use, since the product is unstable.

What is the half-life of Product S0130, Streptozocin?

Streptozocin has a reported half life of 15 to 30 minutes.

How can I make a solution of Product S0130, Streptozocin?

This product dissolves in water at 50 mg/mL to give a light yellow solution, from clear to slightly hazy. We recommend using a 20 mM citrate buffer at pH 4.5 for best solution stability.

CanProduct S0130, Streptozocin, be used to induce diabetes? What concentration should be used?

We do not test Streptozocin, Product No. S0130 for biological activity.We recommend screening lots for biological activity.An intravenous injection of streptozocin into rats at a dose of 65 mg/kg body weight to induce diabetes has been reported by Burcelin R. et al. in Biochem. J., 291, 109-113 (1993).

How do I get lot-specific information or a Certificate of Analysis?

The lot specific COA document can be found by entering the lot number above under the "Documents" section.

How do I find price and availability?

There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.

What is the Department of Transportation shipping information for this product?

Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

My question is not addressed here, how can I contact Technical Service for assistance?

Ask a Scientist here.

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同行評(píng)議文獻(xiàn)

Did you use this product in your Paper? If so click here.

The Streptozotocin-Induced Diabetic Nude Mouse Model: Differences between Animals from Different Sources Melanie L Graham Comparative Medicine 61(4), 356-360, (2011)

Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans Chinedum Journal of diabetes and metabolic disorders 12, 60-60, (2013)

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Delayed inhibition of VEGF signaling after stroke attenuates blood-brain barrier breakdown and improves functional recovery in a comorbidity-dependent manner.

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